There is plenty of parking available:

Valet parking in the Nix Medical Center (enter on College St.)
Discount available for Nix Senior Gold members.

Mid-City Garage (across the street from the hospital; enter on College St.)

South Bank Parking Lot (one block away from the hospital)
Patients of the Nix received discounted parking at both locations.

Driving Directions: 

From IH-37 / 281: Exit Commerce St. Go west on Commerce, and turn right on Navarro.

From IH-10 East: Exit Durango Blvd./ Downtown. Turn right on Durango, and turn left on Santa Rosa. Turn right on Dolorosa (turns into Market St.) and turn left on Navarro.

From IH-35 / IH-10 West: Exit Santa Rosa St./Downtown. Turn left on Dolorosa (turns into Market St.) and turn left on Navarro.